Abcam, ab184917, Anti-Delta-catenin antibody [EPR17628]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Delta-catenin antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17628,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Delta-catenin also known as CTNND2 or Neurojungin is an important protein involved in cellular adhesion processes. With a molecular mass of around 122 kDa Delta-catenin is found mainly in the brain and nervous system tissues. It is a member of the armadillo/β-catenin superfamily and plays a significant role in the structure and function of synapses connecting cytoskeletal components to cell junctions. Its expression is most prominent in neurons suggesting a function important to neuronal development and maintenance.
Biological function summary
Delta-catenin associates with and is part of the cadherin-catenin complex facilitating cell-cell adhesion in neuronal cells. This complex supports the stabilization of adherens junctions influencing cell shape signaling and gene transcription. Delta-catenin's interaction with cadherin proteins helps regulate synaptic plasticity and dendritic spine development impacting learning and memory processes within the brain.
Pathways
Delta-catenin contributes significantly to the Wnt signaling pathway. It plays a role in cellular edge interactions and migration by modulating cadherin-mediated adhesion and Rho GTPase signaling. In collaboration with proteins such as β-catenin Delta-catenin influences processes linked to cell morphological changes and neurodevelopmental regulation. It acts as a mediator between intracellular signaling and intercellular communication impacting neurogenesis.
Delta-catenin has potential links to neurodevelopmental disorders like autism spectrum disorder (ASD) and Alzheimer's disease. Alterations in Delta-catenin expression and mutations correlate with cognitive dysfunction and synaptic impairments observed in these conditions. In Alzheimer's disease Delta-catenin's interaction with β-amyloid and presenilin-1 proteins can exacerbate synaptic loss and memory deficits identifying it as a possible target in understanding disease mechanisms and therapeutic intervention.