Abcam, ab184973, Anti-LIN37 antibody

Size: 100µL
Rabbit Polyclonal LIN37 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LIN37 aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LIN37 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96GY3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIN37 also known as Lin-37 DREAM complex component or 37 kDa protein is a component of the DREAM (DP RB-like E2F and MuvB) complex. This protein weighs approximately 37 kDa. It is predominantly expressed in proliferating tissues and plays an important role in controlling cell cycle progression. LIN37 localizes mainly to the nucleus where it carries out its function.
Biological function summary
LIN37 operates as part of the DREAM complex which is essential for regulating cell cycle-dependent gene expression. The DREAM complex consists of other proteins such as LIN9 LIN52 and RBL1. LIN37 helps repress genes that promote DNA replication and mitosis during the quiescent phase where cells are not actively dividing. By cooperating with other complex members it helps maintain cellular homeostasis and prevent unnecessary cell division.
Pathways
LIN37 and its role in the DREAM complex impact the control of the Rb-E2F pathway. This pathway regulates the transcription of genes required for cell cycle progression. Through the interplay with RBL1 and E2F4 LIN37 contributes to cell cycle exit and entry ensuring the cells only progress to DNA synthesis when necessary. The complex finely tunes cell cycle events to maintain balanced proliferation.
LIN37 has a noted association with certain cancers such as retinoblastoma. Disruption in the DREAM complex including LIN37 function may lead to derepression of genes necessary for DNA synthesis and mitosis contributing to uncontrolled cell proliferation. LIN37's interactions with proteins like RBL2 emphasize its significance in tumor suppression presenting potential therapeutic targets for cancer interventions.