Abcam, ab185106, Anti-ZASC1 antibody

Size: 100µL
Rabbit Polyclonal ZASC1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF639 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF639 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q9UID6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZASC1 also known as Zinc finger protein 618 with SCAN box is a transcription factor characterized by the presence of a SCAN domain and multiple zinc finger motifs. It has an approximate molecular mass of 93 kDa. This protein is largely expressed in the testis with lower levels present in additional tissues such as the heart and brain. The presence of zinc finger domains indicates its potential role in DNA binding and gene regulation.
Biological function summary
ZASC1 is involved in modulating the transcriptional activities of genes by binding to specific DNA sequences. In its function as a transcription factor ZASC1 interacts with other proteins to form a regulatory complex that influences gene expression patterns. This protein plays a role in cellular processes such as differentiation and proliferation by impacting the transcription of genes necessary for these processes.
Pathways
ZASC1 participates in several essential cellular pathways including those linked to gene expression regulation in the cell cycle. Within these pathways it works in conjunction with other transcription factors and signaling proteins such as the CREB-binding protein to fine-tune the transcriptional response. This interaction serves to coordinate the cellular activities important for maintaining normal function and development.
ZASC1 has implications in conditions like cancer and infertility. Altered expression or mutations in its coding sequence are associated with the dysregulation of cell growth implicating it in oncogenic processes. It also associates with other proteins like c-Myc in various cancer types highlighting its significance in cancer biology. Additionally inappropriate expression of ZASC1 may disrupt spermatogenesis leading to infertility highlighting its importance in reproductive health.