Abcam, ab18529, Anti-LAMP2B antibody - Lysosome Marker

Size: 100µg
Rabbit Polyclonal LAMP2 antibody. Lysosome marker. Suitable for WB and reacts with Human samples. Cited in 34 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This product has low sequence homology with Mouse LAMP2B (67%), and high sequence homology with Mouse LAMP2C (91.7%).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LAMP2B also known as lysosome-associated membrane glycoprotein 2b acts mechanically as a lysosomal protein essential for normal cellular function. It has a mass of approximately 45 kDa and is highly expressed in tissues such as the heart skeletal muscle and liver. The protein integrates into the lysosomal membrane contributing to cellular degradation processes and maintaining lysosomal integrity.
Biological function summary
LAMP2B facilitates lysosomal fusion with autophagosomes aiding the process of autophagy important for cellular maintenance and survival. It forms part of a complex involved in chaperone-mediated autophagy a specific system of protein degradation. This adaptation prevents intracellular damage with LAMP2B playing a critical role in maintaining cellular homeostasis.
Pathways
Studies indicate that LAMP2B is significantly involved in the autophagy-lysosome pathway. It works alongside key proteins like LC3 and Beclin-1 which drive the formation and function of autophagosomes. Through this LAMP2B influences cellular recycling and energy balance linking it closely to cellular stress response and homeostatic regulations.
LAMP2B deficiency can lead to Danon disease a severe condition characterized by cardiomyopathy and muscle weakness. Research also links LAMP2B dysfunction to Parkinson's disease where it interacts with proteins such as alpha-synuclein suggesting a role in neurodegenerative processes. Ensuring proper LAMP2B function is essential to prevent these disorders.