Abcam, ab186001, Anti-HMGN5 antibody

Size: 100µg
Rabbit Polyclonal HMGN5 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HMGN5 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HMGN5 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P82970

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HMGN5 protein also known as Nsbp1 belongs to the high mobility group (HMG) proteins. It has a molecular mass of approximately 30 kDa. This protein localizes mainly in the nucleus where it binds to nucleosomes influencing chromatin structure and gene expression. Unlike certain other HMG proteins that express in specific tissues HMGN5 shows broad expression across different tissues indicating its varied role in cellular functions.
Biological function summary
HMGN5 functions by modulating chromatin accessibility impacting transcription and replication. It forms part of a complex involved in chromatin remodeling. By affecting chromatin dynamics HMGN5 influences the expression of genes important for cell cycle and differentiation processes. Such influence highlights its role in maintaining genomic stability and regulating cellular responses.
Pathways
HMGN5 plays a role in pathways related to chromatin remodeling and gene transcription. It interacts with proteins involved in the MAPK signaling pathway which is important for cell growth and differentiation. Moreover HMGN5 has associations with the p53 protein pathway contributing to the regulation of cell cycle checkpoints and apoptosis decisions.
HMGN5 has connections to cancer and certain neurological disorders. Its overexpression has been linked to the progression of various cancers such as prostate cancer by altering gene expression and promoting tumorigenesis. In some neurological disorders abnormalities in HMGN5 expression may affect neural cell development and function. Through these conditions HMGN5 often interacts with proteins like p53 and other cell cycle regulators.