Abcam, ab186009, Anti-FTSJ3 antibody - N-terminal

Size: 100µg
Rabbit Polyclonal FTSJ3 antibody. N-terminal. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FTSJ3 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FTSJ3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q8IY81

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab186009 was affinity purified using an epitope specific to FTSJ3 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FTSJ3 also known as mitochondrial ribosomal RNA methyltransferase 3 is an enzyme with a mass of approximately 84 kDa. The protein is part of the FtsJ/hEN1 family and plays a role in RNA modification by adding methyl groups to ribosomal RNA (rRNA) impacting ribosome assembly and function. FTSJ3 is ubiquitously expressed with high levels in tissues like the heart liver and skeletal muscle indicating its importance for metabolic activity and protein synthesis.
Biological function summary
FTSJ3 functions as an rRNA methyltransferase that is important for the maintenance of mitochondrial ribosome stability. It is a component of the mitoribosome complex which is responsible for mitochondrial protein synthesis. This activity is essential for cellular energy production as it directly affects the translation of mitochondrial-encoded genes required for oxidative phosphorylation.
Pathways
FTSJ3 plays a role in mitochondrial gene expression pathways and its activity affects the oxidative phosphorylation pathway a fundamental process for ATP production. This protein works alongside related proteins like METTL12 which has complementary roles in RNA modification ensuring the stability and efficiency of mitochondrial translation machinery.
Disruptions in FTSJ3 function associate with mitochondrial diseases that involve energy deficiencies such as Leigh syndrome and mitochondrial encephalomyopathy. The protein's dysfunction can also impact neurological disorders due to its critical role in energy production connecting it to proteins like GFM1 and MRPS7 which are also involved in mitochondrial translation and whose dysfunctions similarly contribute to mitochondrial pathologies.