Abcam, ab186433, Anti-C10orf63 antibody [EPR14013]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal C10orf63 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14013,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C10orf63 also known as TMEM119 is a protein that plays a critical role in cellular processes. It has a molecular weight of approximately 54 kDa and is predominantly expressed in microglial cells within the central nervous system. TMEM119 localizes to the plasma membrane contributing to the regulation of specific signaling pathways.
Biological function summary
TMEM119 serves to regulate immune responses in the brain participating as part of a larger complex involving other membrane proteins. It is integral in maintaining microglial identity and function. TMEM119 influences processes such as cell activation migration and phagocytosis. By doing so it contributes to the homeostasis and defense mechanisms in the neural environment.
Pathways
TMEM119 is involved in the TLR4 signaling pathway which is essential for the innate immune responses. It interacts with proteins such as MyD88 which transduces downstream inflammatory signaling cascades. TMEM119's role in this pathway ensures precise control over inflammatory responses and cellular activation which are critically important in the brain's microenvironment.
TMEM119 has a notable connection to neuroinflammation and neurodegenerative diseases particularly Alzheimer's disease and multiple sclerosis. In Alzheimer's disease TMEM119 interaction with proteins like TREM2 suggests a role in modulating inflammatory responses and amyloid-beta phagocytosis. Similarly in multiple sclerosis altered TMEM119 expression can influence microglial activity and contribute to disease progression revealing its importance in pathological conditions.