Abcam, ab187147, Anti-PGAM2 antibody [EPR15194(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PGAM2 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15194(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PGAM2 or phosphoglycerate mutase 2 is an enzyme and plays an important role in glycolysis. This enzyme catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate. PGAM2 is known for its molecular weight of approximately 29 kDa. It expresses in skeletal muscle tissue predominantly allowing it to help meet the energy demands during muscle contraction. The activity of PGAM2 is essential in tissues that require high energy supply.
Biological function summary
The enzyme PGAM2 is important in energy metabolism within the cells. It participates in the glycolytic pathway which leads to ATP production necessary for cell survival and functioning. PGAM2 acts as part of the glycolytic enzyme complex. By enabling the conversion of intermediates PGAM2 facilitates the continuous flow of the glycolytic cascade necessary for efficient energy extraction from glucose.
Pathways
PGAM2's function is central in glycolysis and gluconeogenesis. These pathways are essential for energy production and glucose homeostasis respectively. It collaborates with proteins such as enolase the enzyme responsible for converting 2-phosphoglycerate to phosphoenolpyruvate further down the glycolytic pathway. These interactions support the efficient production of ATP and gluconeogenic capabilities of the liver and kidney where energy conservation and storage are fundamental.
PGAM2 deficiency has connections to metabolic and muscular conditions. One of the diseases associated with PGAM2 is glycogen storage disease type X also known as muscle phosphoglycerate mutase deficiency. It affects muscle function by disrupting glycolysis. Additionally aberrations in PGAM2 activity can associate with metabolic dysfunctions often connected to proteins such as lactate dehydrogenase which gatekeeps the final steps of anaerobic glycolysis. Studying PGAM2 deeply and its links to these diseases provides insights for potential therapeutic targets.