Abcam, ab187162, Anti-NBEAL2 antibody [EPR14501(B)] - N-terminal

Size: 10µL-TRIAL / 100µL / 1mL
Rabbit Recombinant Monoclonal NBEAL2 antibody. N-terminal. Suitable for WB and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14501(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NBEAL2 protein also known as Neurobeachin-like 2 functions as a large protein with a mass of approximately 304 kDa. It has an important role in vesicle-mediated transport within cells. NBEAL2 is expressed mostly in hematopoietic tissues including bone marrow and peripheral blood. The protein structure includes a BEACH domain WD repeats and a leucine zipper motif which contribute to its involvement in cellular trafficking processes.
Biological function summary
The NBEAL2 protein plays an important role in platelet formation and maintenance. It appears necessary for the development of α-granules in platelets which are essential for proper blood clotting. These α-granules store numerous proteins such as clotting factors that are important in hemostasis. While NBEAL2 does not form its own complex it interacts with various cellular machinery involved in vesicle trafficking.
Pathways
NBEAL2 serves as a critical component in pathways regulating platelet production and release. Its functions intersect with the megakaryocyte development pathway an essential pathway for platelet biogenesis. NBEAL2 shows close interaction with proteins like WASP which also contribute to thrombopoiesis. Its activity ensures the proper formation and function of platelet precursor cells.
Several findings connect the NBEAL2 protein to gray platelet syndrome (GPS). GPS is a rare bleeding disorder characterized by the deficiency or absence of α-granules in platelets. Mutations in NBEAL2 are frequently linked to the development of this syndrome. Moreover the protein's role in platelet function also ties it to potential contributions in disorders related to thrombosis. Understanding NBEAL2's interactions especially with other proteins involved in platelet formation like MYH9 offers further insights into its implications in hematological conditions.