Abcam, ab187166, Anti-TRRAP antibody [EPR14952-81]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TRRAP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14952-81,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TRRAP (Transformation/Transcription Domain-Associated Protein) also known simply as TRAAP acts as an adaptor protein with a molecular weight of approximately 434 kDa. TRRAP is widely expressed across different tissue types playing a significant role in cellular processes. As part of a larger family of proteins linked to phosphoinositide 3-kinase-related kinases TRRAP does not perform any kinase activity despite having a structure similar to these kinases. Its primary function involves facilitating chromatin remodeling and histone acetylation.
Biological function summary
TRRAP functions as part of several multiprotein acetyltransferase complexes notably the Tip60 and SAGA complexes. These complexes modify chromatin structures affecting transcription by acetylating histone proteins which allows genes to be more accessible for transcription. This role is important for regulating gene expression making TRRAP important in cellular differentiation and proliferation. By interacting with specific compartments of the cell it participates in large chromatin-modifying machines that influence cellular outcomes.
Pathways
You will find TRRAP involved in pivotal biological routes such as the DNA damage response and Wnt signaling. In the DNA damage response pathway TRRAP interacts with Histone H4 and influences DNA repair mechanisms. TRRAP also collaborates with proteins like c-MYC in these signaling networks impacting both gene transcription and cell cycle progression. Through its associations with these pathways TRRAP assists in processes that maintain genome stability contributing to normal and pathological cellular states.
TRRAP demonstrates a notable connection to cancer and neurological disorders. Mutations and aberrations in TRRAP expression levels have associations with various cancers including breast and colorectal tumors likely due to its influence on cell proliferation and survival. In the context of neurological disorders deficient TRRAP activity might relate to problems in neural development further highlighting its interaction with c-MYC in maintaining proper cellular growth balance. Understanding TRRAP's function and interactions can offer valuable insights into its role in disease mechanisms.