Abcam, ab187669, Anti-HESP antibody [EPR12943(2)-44]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal HESP antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12943(2)-44,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Hesperetin (HESP) is a small flavonoid with a molecular mass of approximately 302.27 Da. It commonly appears in citrus fruits. This molecule shows significant expression across various plant cells where it functions as both an antioxidant and an anti-inflammatory agent. Hesperetin is also known for its role in modulating enzyme activities affecting several oxidative processes within the cells.
Biological function summary
Hesperetin plays a role in numerous cellular processes. It exhibits its effects mainly through interactions with cellular enzymes affecting the modulation of signal transduction pathways. Hesperetin operates partially within complexes that influence the cell's response to oxidative stress and inflammatory markers. Its ability to interact with these components highlights its importance in maintaining cellular homeostasis and preventing cellular damage.
Pathways
Hesperetin is integral to both the flavonoid biosynthesis and the oxidative stress response pathways. These pathways are vital for reducing reactive oxidative species (ROS) and enhancing the cell's defense mechanisms. In these contexts hesperetin relates to proteins like NADPH oxidase and enzymes involved in the detoxification of ROS. Hesperetin together with these proteins contributes to modulating redox homeostasis within cells.
Hesperetin connects to cardiovascular disease and certain cancers. It helps reduce inflammation and oxidative stress two key factors in the pathogenesis of these conditions. During these disease states hesperetin associates with proteins such as NF-kB and COX-2 both of which play roles in inflammatory pathways. This connection makes HESP a target of interest for therapeutic intervention and research in disease-modifying therapies.