Abcam, ab187697, Anti-TTLL5 antibody

Size: 100µg
Rabbit Polyclonal TTLL5 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TTLL5 aa 1200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TTLL5 aa 1200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6EMB2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TTLL5 or Tubulin Tyrosine Ligase Like 5 acts as an enzyme that adds glutamates onto tubulin a process known as polyglutamylation. It has an approximate mass of 121 kDa. This protein is expressed in various tissues with higher levels observed in the retinal photoreceptor cells and testes. TTLL5 plays a role in the post-translational modification of proteins which is essential for the functioning of the microtubule network.
Biological function summary
TTLL5 contributes to cellular processes by modifying tubulin a critical component of the cytoskeleton. In its role it performs polyglutamylation affecting microtubule stability and interactions with microtubule-associated proteins (MAPs) and motor proteins. TTLL5 functions as a part of a larger group of enzymes similar to other members of the tubulin tyrosine ligase-like family which regulates the different aspects of microtubule dynamics.
Pathways
TTLL5 is important in the MAPK signaling pathway and axon guidance. In these pathways TTLL5 affects cellular morphology and signaling by modifying tubulin structures which may regulate the activity of proteins like MAP2 and tau impacting cell transport and division. Its role in these pathways highlights the significance of microtubule modifications in both cellular signaling and structural integrity.
Mutations or dysregulation of TTLL5 have been linked to retinal degeneration and ciliary dysfunction disorders. In retinal degeneration TTLL5 defects affect photoreceptor cell functions due to improper protein modification. The protein’s impact on the disease connects through interaction with other microtubule-related proteins which are also critical for maintaining retinal cell structure and function.