Abcam, ab187885, Anti-ASAP3 antibody

Size: 100µL
Rabbit Polyclonal ASAP3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ASAP3 aa 650-800.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ASAP3 aa 650-800. The exact immunogen used to generate this antibody is proprietary information.Q8TDY4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein ASAP3 also known as AMAP3 is part of the ARF GAP (ADP-ribosylation factor GTPase-activating protein) family. It has a molecular mass of approximately 100 kDa and is known to regulate actin cytoskeleton remodeling. Expression of ASAP3 occurs mostly in epithelial tissues. ASAP3 functions as a GTPase-activating protein for ADP-ribosylation factors and plays a significant role in cellular processes such as migration and adhesion.
Biological function summary
ASAP3 influences cell structure and movement by regulating the dynamics of the actin cytoskeleton. It participates in molecular complexes that manage actin-filaments and microtubule interactions critical for maintaining cell shape and motility. Additionally ASAP3 is essential for directional cell movement especially important during tissue development and repair.
Pathways
ASAP3 impacts cellular processes critical for the regulation of the actin cytoskeleton and cell migration. ASAP3 modulates signaling pathways including the Rho family small GTPases which involve proteins like Rac1 and Cdc42 that coordinate complex cellular movements. These pathways ensure proper cellular responses to external stimuli by orchestrating signaling cascades affecting cell morphology.
ASAP3 is associated with the progression of cancer particularly within the context of increased migration and invasion of tumor cells. Studies highlight its interaction with the protein EGFR (epidermal growth factor receptor) which plays a role in oncogenic pathways. Furthermore alterations in ASAP3 expression have shown links to neurodevelopmental disorders where disruptions in cytoskeleton regulation affect neural cell migration and network formation.