Abcam, ab187978, Anti-MIST-1 antibody

Size: 100µL
Rabbit Polyclonal MIST-1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 13 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BHLHA15 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human BHLHA15 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q7RTS1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The mechanistic function of MIST-1 also known as BHLHA15 involves its role as a transcription factor. MIST-1 has a mass of approximately 29 kDa and is expressed in several tissues including the exocrine pancreas stomach and salivary glands. It is essential in regulating gene expression during cell differentiation. MIST-1 coordinates cellular activities by binding to DNA and influencing the transcription of target genes critical for secretory function in acinar cells.
Biological function summary
MIST-1 plays an important role in the development and maintenance of secretory acinar cells. It forms a complex with other transcription factors to control the genes important for cell structure and secretion. This transcription factor ensures that cells in these tissues maintain their specialized function essential for the production and release of digestive enzymes. MIST-1's function is important for maintaining cellular homeostasis and ensuring proper organ function.
Pathways
The transcriptional regulation role of MIST-1 integrates into the secretory vesicle pathway and the exocytosis pathway. It coordinates with proteins such as C/EBPα and C/EBPβ in acinar cell function influencing the secretion of digestive enzymes. MIST-1 aligns with other components within these pathways impacting the vesicular transport mechanisms that are important for proper enzyme release and digestive processes.
MIST-1 plays an important role in pancreatic diseases and gastric disorders. Its dysfunction can lead to impaired secretion and cellular pathology which are linked to conditions such as pancreatitis and gastric metaplasia. MIST-1's interaction with other proteins like C/EBPβ is critical in maintaining cellular integrity within the pancreas and disruptions in these interactions may contribute to disease progression and severity.