Abcam, ab188239, Anti-USP26 antibody

Size: 100µL
Rabbit Polyclonal USP26 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human USP26 aa 500-800.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human USP26 aa 500-800. The exact immunogen used to generate this antibody is proprietary information.Q9BXU7

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.05% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
USP26 also known as Ubiquitin Specific Peptidase 26 is an enzyme that removes ubiquitin moieties from specific proteins regulating their degradation localization or activity. USP26 is part of the deubiquitinating enzymes (DUBs) family and has a molecular mass of approximately 104 kDa. It expresses mainly in testicular tissue which indicates its role in reproductive biology.
Biological function summary
The enzyme plays a role in spermatogenesis the process of sperm cell development. It participates in the regulation of the androgen receptor (AR) signaling pathway. By interacting with receptors it stabilizes and modulates their activity contributing to normal testicular function. This connects USP26 to a protein complex involving androgen receptors which are essential for male reproductive health.
Pathways
The deubiquitinating activity of USP26 influences the androgen receptor signaling pathway important for male reproductive processes. In the ubiquitin-proteasome system USP26 modulates the stability of the AR receptor and other proteins related to this pathway which may include factors like HSP90 that aid in receptor activation and stabilization.
Anomalies in USP26 function correlate with male infertility. Mutations or altered expression are linked to disorders in spermatogenesis. This has connections with androgen receptor abnormalities as proper receptor function is necessary for normal sperm production. Studies also find indications that dysregulation may link to prostate cancer where androgen receptor involvement is critical.