Abcam, ab188345, Anti-CWC15 antibody

Size: 100µL
Rabbit Polyclonal CWC15 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CWC15 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CWC15 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9P013

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CWC15 also known as CWC15 spliceosome-associated protein homolog plays a role in RNA splicing. It is a protein with a mass of approximately 16 kDa. CWC15 is expressed in various human tissues but it shows higher expression in hematopoietic cells. Its mechanical function involves facilitating the splicing of pre-mRNA by associating with the spliceosome a large ribonucleoprotein complex.
Biological function summary
CWC15 contributes to RNA processing within cells. It forms part of the spliceosome complex which is critical for the modification of pre-mRNA to mature mRNA. This modification process is necessary for proper gene expression and cellular function. The influence of CWC15 in this complex underlines its importance in regulating the correct removal of introns and the joining of exons ensuring that mature mRNA accurately reflects genetic coding.
Pathways
CWC15 has connections to the mRNA splicing pathway and RNA transport. It interacts with other spliceosomal proteins like PRPF8 and SNRNP200 facilitating efficient splicing activity. These interactions ensure the proper flow of genetic information from DNA to functional proteins impacting the gene expression pathway that maintains cellular homeostasis.
CWC15 has associations with myelodysplastic syndromes and acute myeloid leukemia. These diseases relate to its role in RNA splicing which if altered can lead to abnormalities in hematopoietic cells. Its interaction with PRPF8 a protein implicated in similar conditions suggests a critical contribution of CWC15 to maintaining normal cellular function and preventing malignancies in hematopoietic tissues.