Abcam, ab188637, Anti-GPR133 antibody - N-terminal

Size: 50µg
Rabbit Polyclonal GPR133 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ADGRD1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ADGRD1. The exact immunogen used to generate this antibody is proprietary information.Q6QNK2,
Specificity:BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except ENTPD4 (50%).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR133 also known as ADGRD1 is a member of the adhesion G protein-coupled receptor (GPCR) family. It possesses a large extracellular domain and a characteristic seven-transmembrane domain typical of GPCRs with a molecular mass approximately 100 kDa. GPR133 expresses broadly in the central nervous system and several peripheral tissues including the lung and heart. This pattern of expression suggests its involvement in various physiological functions.
Biological function summary
Adhesion G protein-coupled receptor GPR133 has roles in cellular signaling and communication. It participates in the regulation of processes such as cell adhesion and migration. GPR133 does not act alone; it associates with other proteins to affect physiological functions though it is not strictly part of a larger protein complex. Its broad expression in several tissues indicates its functional versatility.
Pathways
Research links GPR133 to significant signaling pathways like the Wnt signaling pathway and the G-protein signaling pathway. It interacts with the proteins involved in these pathways to modulate their downstream effects impacting cellular processes such as proliferation and differentiation. Partner proteins such as heterotrimeric G proteins directly associate with GPR133 playing roles in the signal transduction processes initiated by this receptor.
GPR133 associates with conditions such as glioblastoma and asthma. It often operates alongside other proteins involved in these conditions such as EGFR in glioblastoma and the IL-4 receptor in asthma. Alterations in the expression or function of GPR133 may contribute to the pathogenesis of these diseases by affecting cell signaling pathways presenting it as a potential therapeutic target for intervention.