Abcam, ab188746, Anti-RXFP1 antibody - N-terminal

Size: 50µg
Rabbit Polyclonal RXFP1 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RXFP1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RXFP1. The exact immunogen used to generate this antibody is proprietary information.Q9HBX9,
Specificity:BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Relaxin Family Peptide Receptor 1 commonly known as RXFP1 is a G protein-coupled receptor with a mass that can vary depending on post-translational modifications but is purified at roughly 86 kDa. RXFP1 is mainly expressed in reproductive tissues such as the uterus and cervix as well as in the heart blood vessels and kidneys. It binds with its ligand relaxin to initiate intracellular signaling cascades that activate various physiological responses.
Biological function summary
RXFP1 plays important roles in reproductive and cardiovascular systems. It facilitates the actions of relaxin often as part of a receptor-ligand complex leading to vasodilation extracellular matrix remodeling and collagen degradation. These functions enable tissue growth and flexibility especially during pregnancy and maintain homeostasis in cardiovascular conditions by influencing heart rate and blood flow.
Pathways
RXFP1 figures prominently in the nitric oxide signaling pathway and the cAMP-dependent pathway. The receptor's activation by relaxin promotes nitric oxide production which leads to vasodilation and decreased vascular resistance. It also initiates the cAMP pathway by coupling with G-proteins to increase cAMP levels which further amplifies vasodilation effects. These pathways involve proteins such as nitric oxide synthase and adenylate cyclase that interact directly or indirectly with RXFP1.
RXFP1's role is particularly significant in fibrotic diseases and heart failure. Improper regulation of RXFP1-mediated collagen remodeling can contribute to tissue fibrosis with relaxin and collagen being the critical proteins in this process. Moreover the receptor's ability to mediate vasodilation and reduce cardiac load presents it as a potential therapeutic target in heart failure. By affecting these pathways RXFP1 may provide routes to novel treatments for such debilitating conditions.