Abcam, ab189174, Anti-Nicotinic Acetylcholine Receptor beta 2/CHRNB2 antibody

Size: 50µg
Goat Polyclonal Nicotinic Acetylcholine Receptor beta 2/CHRNB2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CHRNB2 aa 350-400.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CHRNB2 aa 350-400. The exact immunogen used to generate this antibody is proprietary information.P17787

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Nicotinic Acetylcholine Receptor beta 2 (CHRNB2) also known as nAChR beta-2 subunit is an integral membrane protein involved in forming ligand-gated ion channels. It has a pivotal role in neurotransmission by responding to the neurotransmitter acetylcholine. CHRNB2 typically forms heteromeric complexes with alpha subunits to yield functional receptors. It is highly expressed in the central nervous system including regions such as the cerebral cortex and hippocampus. Each beta-2 subunit has a molecular mass of approximately 50 kDa.
Biological function summary
CHRNB2 influences synaptic plasticity and cognitive processes. It functions as part of a pentameric receptor complex usually composed of various subunits that determine the receptor's physiological properties. The receptor modulates neurotransmitter release and impacts neuronal excitability. Its activity contributes to cognitive functions such as attention learning and memory mediated through ion flow across cell membranes that affect neuron firing rates.
Pathways
The beta-2 subunit of the nicotinic acetylcholine receptor is integral to the cholinergic pathway. It interacts with the dopaminergic system by modulating dopaminergic neuron activity and dopamine release. This interaction plays a significant role in pathways related to reward pleasure and addiction. Proteins such as the dopamine transporter (DAT) are closely linked within these pathways affecting the dynamics of neurotransmitter availability and receptor activation.
Alterations in CHRNB2 function associate with neurological disorders like nicotine addiction and Alzheimer's disease. Dysfunctional receptors due to mutations can disrupt cognitive function and behavior highlighting their role in Alzheimer's pathology where neuronal communication is impaired. Other proteins such as amyloid precursor protein (APP) link CHRNB2 to the disease process by influencing neurodegenerative outcomes and synaptic maintenance.