Abcam, ab189253, Anti-TMEM9B antibody [EPR14339]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TMEM9B antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14339,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM9B also known as Transmembrane Protein 9B is a protein involved in cellular processes like signal transduction and membrane trafficking. The protein has a molecular mass of approximately 28.5 kDa. TMEM9B expresses in various tissues including liver and spleen suggesting its role in multiple cellular functions. It localizes primarily to the endosomal and lysosomal membranes where it participates in cellular homeostasis and signaling pathways.
Biological function summary
This protein is involved in several cell functions beyond simple signal transduction. TMEM9B mediates immune responses and regulates inflammatory processes. It does not act in isolation; instead it forms part of larger protein complexes that influence endosomal maturation and acidification therefore enabling effective lysosomal function. This regulation is important for maintaining cellular integrity through proper endocytosis and degradation of cellular debris.
Pathways
TMEM9B plays a significant role within the NF-kB signaling pathway and Toll-like receptor pathways. In the NF-kB pathway TMEM9B interacts with proteins like IKK complexes influencing inflammatory responses at a cellular level. In the Toll-like receptor pathway its interaction with adaptor molecules such as MyD88 aids in initiating immune defense mechanisms. These interactions allow TMEM9B to serve as an important regulator in maintaining cellular and systemic inflammatory balance.
TMEM9B shows association with conditions like rheumatoid arthritis and systemic lupus erythematosus. These associations arise due to its regulation of inflammation and immune responses. The protein’s involvement in these conditions reveals an interaction with other key regulators like TNF-alpha and interleukin-6 which are pivotal in inflammatory diseases. Understanding TMEM9B involvement in such disorders may provide novel therapeutic targets for managing chronic inflammatory conditions.