Abcam, ab18929, Anti-Hepatitis C Virus Core Antigen antibody [11-B3]

Size: 100µg
Mouse Monoclonal POLG antibody. Suitable for ELISA, WB, IHC-Fr and reacts with Hepatitis C virus samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:11-B3,
Isotype:IgG1,
Carrier free:No,
Reacts with:Hepatitis C virus,
Applications:IHC-Fr, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Epitope:Amino acids 70-90.

Product details:
Mouse monoclonal [11-B3] to Hepatitis C Virus Core Antigen (ab18929) stains primarily cytoplasmic; mainly in the perinuclear area.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.2 - 7.6Preservative: 0.01% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Hepatitis C Virus Core Antigen also known as HCV Core Protein or simply HCV Core is an essential structural component of the Hepatitis C virus. This protein with a mass of approximately 21 kDa plays a fundamental role in the formation of the viral nucleocapsid. It expresses extensively in the liver cells of infected individuals serving as a target for the diagnostic 'anti-HCV ELISA'. The HCV Core Protein interacts with host cellular machinery facilitating viral replication and pathogenesis.
Biological function summary
The HCV Core Protein influences various cellular processes and immune responses in the host. It can modulate the host's gene expression interfere with cell signaling and affect apoptosis thereby promoting viral persistence. The protein often forms a part of heterogeneous complexes interacting with both viral and host proteins to alter cellular environments in favor of viral replication. This multifaceted role makes it an important target for research in understanding hepatitis C pathogenesis.
Pathways
The HCV Core Protein participates in disrupting signaling pathways such as the NF-kB and TGF-beta pathways. In these pathways HCV Core can bind with cellular proteins that are key regulators including p53 and retinoblastoma protein to exert its effects on cell cycle regulation and immune modulation. These interactions help the virus to counteract antiviral responses and contribute to liver diseases.
The HCV Core Protein is closely associated with hepatitis C infection and its progression to liver cirrhosis and hepatocellular carcinoma. By interacting with proteins like the tumor suppressor p53 the core protein plays a role in the development of liver cancer. Understanding these interactions is important in developing therapeutic strategies to combat the effects of chronic hepatitis C infection.