Abcam, ab189428, Anti-TAF4B antibody - C-terminal

Size: 200µL
Rabbit Polyclonal TAF4B antibody. C-terminal. Suitable for WB, IHC-P, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TAF4B aa 650-700 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TAF4B aa 650-700 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q92750

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAF4B also known as TBP-associated factor 4B is a protein important in transcription initiation. This protein is part of the TFIID complex and has a mass of approximately 85 kDa. It is expressed in various tissues including ovaries and testes. TAF4B facilitates interactions between TBP (TATA-binding protein) and other transcription factors promoting the assembly of pre-initiation complexes on gene promoters.
Biological function summary
TAF4B has significant roles in regulating gene expression. It forms part of the multi-subunit TFIID complex. Through this association TAF4B is involved in the transcription of genes required for cell cycle progression and development. Its expression levels and regulation affect cellular differentiation and growth making it essential for normal cellular functions especially in reproductive tissues.
Pathways
TAF4B participates in key biological processes such as the RNA polymerase II pre-initiation complex formation. It interacts with other TAFs (TBP-associated factors) and transcriptional activators that modulate gene expression in response to cellular signals. In particular the estrogen signaling pathway has a link with TAF4B influencing gene transcription in reproductive tissues. This protein works closely with other components of the TFIID complex to ensure accurate transcriptional regulation.
Alterations in TAF4B expression or function associate with conditions like infertility and ovarian dysfunction. In reproductive disorders its expression levels may impact genes imperative for gonadal development. TAF4B's interaction with estrogen receptors also suggests potential connections to disorders influenced by hormonal imbalances though more studies are needed to fully define these links and associated proteins.