Abcam, ab189518, Anti-USP19 antibody [EPR14816]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal USP19 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR14816,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
USP19 also known as Ubiquitin Specific Peptidase 19 is an enzyme with deubiquitinating activity. It belongs to the family of cysteine proteases and has a molecular mass of approximately 150 kDa. This protein's primary function involves the removal of ubiquitin from specific protein substrates regulating their degradation and maintaining protein homeostasis. USP19 is expressed in multiple tissues including skeletal muscle heart and brain indicating its widespread physiological roles.
Biological function summary
The regulation of protein turnover and cellular stress responses involves USP19. As a standalone enzyme it participates independently rather than as part of a larger protein complex. By deubiquitinating target proteins USP19 influences their stability and function affecting a variety of cellular processes such as protein synthesis cell cycle progression and stress response through modulation of ubiquitin chains on substrates.
Pathways
The modulation of protein degradative pathways involves USP19 specifically impacting the ubiquitin-proteasome system (UPS) and chaperone-mediated autophagy (CMA). It interacts with key proteins in these pathways such as ubiquitin-conjugating enzymes and proteasomal subunits to maintain cellular homeostasis. By regulating pathways like UPS USP19 plays a role in controlling protein quality and preventing aggregation which is critical for cell function.
The dysregulation of protein degradation mechanisms implicates USP19 in conditions such as muscle atrophy and neurodegenerative diseases. Abnormal activity of USP19 associates with disorders like Parkinson’s disease where it may interact with proteins such as Parkin affecting the ubiquitination balance. Studies on USP19 continue to explore its potential as a therapeutic target for treating these conditions.