Abcam, ab189653, Anti-SnoN/SNO antibody - N-terminal

Size: 50µg
Rabbit Polyclonal SnoN/SNO antibody. N-terminal. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SKIL.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SKIL. The exact immunogen used to generate this antibody is proprietary information.P12757

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SnoN also known as SNO is a transcriptional co-repressor that plays a significant role in cellular signaling. It has a molecular mass of approximately 75 kDa and is expressed in various tissues including the brain liver and muscle. The protein serves as an important regulator by interacting with different transcription factors influencing gene expression. SnoN is often involved in negative regulation of the transforming growth factor-beta (TGF-β) signaling pathway acting through binding and repressing activities of Smad proteins.
Biological function summary
SnoN influences cell growth and differentiation. It exists as part of a complex with other co-repressors and transcription factors particularly within the TGF-β signaling pathway. SnoN modulates the balance between cell proliferation and apoptosis therefore playing an important role in tissue homeostasis. Its regulation is essential for proper development and maintaining normal cellular function.
Pathways
SnoN has a central role in the TGF-β signaling pathway. This pathway is important for controlling a broad range of cellular processes including proliferation differentiation and apoptosis. Within this pathway SnoN interacts with Smad proteins to regulate gene transcription negatively. Additionally SnoN has connections with the ERK/MAPK pathway which links it to other important cellular processes and growth factor signals that influence cell fate decisions.
SnoN has been associated with cancer development particularly in breast cancer and pancreatic cancer. Its deregulation may lead to uncontrolled cell growth and resistance to apoptosis driven by altered TGF-β signaling. SnoN is connected to other proteins such as Smad2 and Smad4 which are known to play roles in the progression of these cancers. Understanding SnoN's role and interactions might provide new insights into therapeutic targets for treating these diseases.