Abcam, ab190255, Anti-LNPEP antibody - N-terminal

Size: 100µg
Rabbit Polyclonal LNPEP antibody. N-terminal. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LNPEP aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LNPEP aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9UIQ6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab190255 was affinity purified using an epitope specific to LNPEP immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LNPEP also called leucyl/cystinyl aminopeptidase or insulin-regulated membrane aminopeptidase (IRAP) serves as a zinc-dependent aminopeptidase. This protein cleaves N-terminal amino acids from peptide substrates functioning inside various tissues like the heart brain and placenta. The mass of LNPEP is approximately 140 kDa. It associates with the endosome compartment in cells and resides at the plasma membrane linking to vesicular transport processes.
Biological function summary
LNPEP plays a role in peptide hormone regulation and recognition involving itself in glucose homeostasis and blood pressure regulation. It joins part of complexes involved in peptide recycling and processing within endocytic vesicles. This protein regulates the degradation of peptide hormones like oxytocin and vasopressin indicating its function extends to neuropeptide modulation.
Pathways
The activity of LNPEP spans significant biological pathways such as the renin-angiotensin system where it modulates the levels of angiotensin IV impacting cardiovascular functions and influencing blood pressure regulation. It closely relates to proteins like insulin-responsive aminopeptidase and angiotensin IV receptor enhancing its regulatory role within these pathways.
LNPEP significantly links to hypertension and diabetes. The modulation of angiotensin IV by LNPEP directly impacts blood pressure associating its activity with the development and management of hypertension. Additionally LNPEP's impact on glucose uptake and insulin action connects it with diabetic conditions. It exhibits interactions with proteins such as the glucose transporter type 4 (GLUT4) in the context of diabetes highlighting its role in metabolic regulation.