Abcam, ab190287, Anti-MT-ATP6 antibody - C-terminal

Size: 200µL
Goat Polyclonal MT-ATP6 antibody. C-terminal. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human MT-ATP6 aa 1-50.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MT-ATP6 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P00846

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab190287 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MT-ATP6 also known as ATP6 or MT-ATP6 is a protein component of the mitochondrial ATP synthase complex. It weighs around 30 kDa and forms an integral part of the mitochondrial inner membrane. MT-ATP6 is expressed widely in human tissues reflecting its fundamental role in cellular energy production. This protein plays a mechanical role in the proton channel facilitating the conversion of proton motive force to synthesize ATP from ADP and inorganic phosphate during oxidative phosphorylation.
Biological function summary
The MT-ATP6 protein participates in ensuring efficient ATP production which serves as an energy currency in cells. As part of the ATP synthase complex (Complex V of the electron transport chain) MT-ATP6 works with other subunits to achieve this energy conversion. This process is critical for maintaining cellular metabolism and energy-dependent functions in mitochondria. Disruptions in MT-ATP6 can impair the entire complex affecting cellular energy capacity.
Pathways
MT-ATP6 engages in the oxidative phosphorylation pathway. This pathway is important for energy transduction in cells operating alongside pathways like glycolysis and the citric acid cycle. MT-ATP6 interacts with related proteins such as other ATP synthase subunits like ATP5B. Through these connections MT-ATP6 contributes to the pathway’s role in maintaining energy homeostasis necessary for various cellular activities.
Defects in the MT-ATP6 gene can lead to conditions such as Leigh syndrome and neuropathy ataxia and retinitis pigmentosa (NARP) syndrome. These conditions arise from impaired oxidative phosphorylation due to mutations affecting the protein’s function. In these disorders MT-ATP6's malfunction often involves associated proteins like MT-CO1 which forms part of Complex IV exacerbating mitochondrial dysfunctions that impact energy-dependent tissues.