Abcam, ab190655, Anti-LASV GP antibody

Size: 50µg
Rabbit Polyclonal SHMT1 antibody. Suitable for WB and reacts with Synthetic peptide samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Lassa virus Josiah GPC.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Lassa virus Josiah GPC. The exact immunogen used to generate this antibody is proprietary information.P08669

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Lassa virus glycoprotein (LASV GP) functions as an important element in virus entry. This glycoprotein consists of two subunits GP1 and GP2 which undergo cleavage for activation and have a combined molecular mass of approximately 75 kDa. Of the two GP1 facilitates viral attachment to host cells while GP2 mediates membrane fusion. LASV GP primarily expresses on the surface of Lassa virus particles and infected host cells playing an important role in initiating infection.
Biological function summary
The Lassa virus glycoprotein complex facilitates the entry and replication of the virus inside host cells. It requires interaction between GP1 and host cell receptors like alpha-dystroglycan to initiate virus attachment. GP2's fusogenic activity then enables fusion of viral and host membranes allowing viral RNA entry into the host cell cytoplasm. The glycoprotein complex drives viral infectivity and pathogenicity supporting the cross-species transmission of the virus.
Pathways
LASV GP engages the endocytic pathway to deliver viral genetic material into host cells. This process involves the endocytosis and trafficking of virus-receptor complexes to late endosomes. It also coordinates with cellular proteins like cathepsin L for the cleavage necessary to activate membrane fusion. Such interactions with endocytic components highlight LASV GP's centrality in the viral life cycle and host-pathogen interactions.
LASV GP constitutes a fundamental role in Lassa fever pathogenesis. Lassa fever an acute viral hemorrhagic illness manifests after LASV GP mediates effective viral entry and replication in host tissues. The glycoprotein's interaction with host factors like alpha-dystroglycan marks it as a target in therapeutic strategies and vaccine development. The viral glycoprotein's influence on immune evasion and disease severity highlights its significance in the context of Lassa fever research.