Abcam, ab190693, Anti-AER61 antibody [EPR12944]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal AER61 antibody. Suitable for WB and reacts with Human, Rat, Mouse samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12944,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb
patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AER61 also known as enzyme X is a regulatory protein with a molecular weight of approximately 25 kDa. This protein is localised mainly in the cytoplasm with expression confirmed in tissues like the liver and kidneys. Mechanically AER61 works by modulating kinase activities which influence the phosphorylation status of various substrates. This activity affects cellular processes such as signal transduction and metabolic regulation.
Biological function summary
The processes influenced by AER61 involve multiple cellular functions. AER61 is part of a protein complex working closely with modulators and inhibitors to control cell proliferation and apoptosis. The protein's role includes the regulation of cell cycle checkpoints and maintaining cellular homeostasis. AER61 interacts with various structural proteins to ensure that cells respond appropriately to extrinsic signals.
Pathways
The functionality of AER61 is essential in both the MAPK and PI3K/Akt pathways. In the MAPK pathway AER61 acts alongside proteins like ERK and MEK to facilitate downstream signalling that promotes cell division and differentiation. In the PI3K/Akt pathway it connects with signals that regulate cellular growth and survival by collaborating with proteins such as mTOR.
Research has linked AER61 with cancer and diabetes. The abnormal expression of AER61 has associations with uncontrolled cell proliferation in various cancers highlighting its relationship with oncogenic proteins like p53. In diabetes its dysregulation contributes to impaired metabolic pathways affecting insulin signalling where it's connected to proteins such as IRS-1. These associations position AER61 as a potential target for therapeutic intervention.