Abcam, ab190796, Anti-TBLR1/TBL1XR1+TBL1X+TBL1Y antibody [EPR16153]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal TBLR1/TBL1XR1 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Rat, Human, Recombinant full length protein - Human, Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16153,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TBL1 also known as TBLR1/TBL1XR1 and TBL1Y are part of the WD40 repeat-containing proteins each with a mass of approximately 55 kDa. These proteins play a role in the mechanics of transcription regulation and signal transduction. TBL1 and its variants are expressed in various tissues including the brain and liver suggesting a broad functional range. They interact with other protein complexes to modulate the chromatin structure and influence gene expression.
Biological function summary
TBL1 and its related proteins function as integral components of the nuclear receptor corepressor complex. They participate alongside other corepressor proteins to mediate transcriptional silencing. TBL1 proteins recruit enzymatic partners to specific genomic locations facilitating targeted gene repression and contributing to processes like metabolic regulation and circadian rhythm maintenance.
Pathways
TBL1 is significantly involved in the Wnt signaling and NF-kB pathways. In the Wnt pathway it interacts with proteins like beta-catenin to influence cell fate decisions. In the NF-kB pathway TBL1 affects the transcriptional regulation of genes involved in immune and inflammatory responses with targets that include RELA and NFKB1.
TBL1 proteins are associated with conditions such as deafness and cancer. Mutations or dysregulation of TBL1 can lead to sensorineural deafness likely due to its role in cochlear function and maintenance. Moreover TBL1 influences tumor progression by interacting with oncogenic proteins like beta-catenin contributing to cancerous transformations. Understanding these relationships highlights the importance of TBL1 in maintaining cellular homeostasis and its potential as a therapeutic target.