Abcam, ab191192, Anti-SLC6A15 antibody

Size: 100µg
Rabbit Polyclonal SLC6A15 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLC6A15 aa 650-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC6A15 aa 650-700. The exact immunogen used to generate this antibody is proprietary information.Q9H2J7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab191192 was affinity purified using an epitope specific to SLC6A15 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC6A15 also known as sodium-dependent amino acid transporter B(0)AT2 is a protein involved in the transport of amino acids across cellular membranes in a sodium-dependent manner. This protein's mass is approximately 73 kDa. It is expressed mostly in the brain kidney and small intestine where it plays an important role in maintaining amino acid homeostasis within cells.
Biological function summary
The transporter plays a significant role in neurotransmitter regulation by facilitating the uptake of neutral amino acids which serve as precursors for neurotransmitter synthesis. It is not known to be part of a larger complex which allows it functional specificity in the transport processes it mediates. The protein's activity impacts neurological functions and metabolic processes through its influence on amino acid availability.
Pathways
SLC6A15 significantly contributes to amino acid transport pathways particularly those critical for the central nervous system's function. This transporter interacts closely with proteins such as B0AT1 which also participates in similar transport activities. The pathways that incorporate SLC6A15 contribute to maintaining the balance of amino acids in the brain which are necessary for cognitive processes and metabolism.
SLC6A15's dysregulation has been associated with major depressive disorder and obesity. This link may be due to its vital role in amino acid supply for neurotransmitter production and metabolic regulation. Proteins such as serotonin transporter (SERT) might be affected due to alterations in amino acid availability impacting mood and metabolic balance. Understanding this protein's function in these conditions could offer insights into new therapeutic strategies.