Abcam, ab191200, Anti-Hepatocyte Specific Antigen antibody [HSA98]

Size: 500µL
Mouse Monoclonal Hepatocyte Specific Antigen antibody. Suitable for ICC, ICC/IF, IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Hepatocyte Specific Antigen protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:HSA98,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:ICC, IHC-Fr, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab191200 binds to human hepatocytes and the majority of human hepatocellular carcinomas (HCC’s). The antibody detects a target on the Cell surface of hepatocytes.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Hepatocyte Specific Antigen also known as OCH1E5 functions as an important identifier of hepatocytes. This antigen with a mass around 66 kDa is expressed significantly in liver tissues. Researchers often use it as a hepatocyte marker in studies and experiments facilitating the recognition and analysis of liver cells. Its specificity makes it a useful tool in hepatocyte flow cytometry and in histological investigations where defining cell type is important.
Biological function summary
The Hepatocyte Specific Antigen participates in the maintenance and function of liver cells. It does not belong to a known complex itself but plays a role in the structural and functional characterization of hepatocytes. These cells' proper function is essential for metabolic processes detoxification and production of vital proteins. Recognizing hepatocyte markers aids in understanding liver health and disease states.
Pathways
The Hepatocyte Specific Antigen is pivotal for identifying hepatocyte involvement in metabolic pathways such as bile acid biosynthesis and glycolysis. Its presence helps delineate pathways that include proteins like Albumin and Cytochrome P450 both critically involved in liver-specific functions. These pathways highlight the liver's key roles in metabolism and detoxification informed by precise cellular identification.
Hepatocyte Specific Antigen serves as a focal point in studying liver diseases such as hepatitis and liver cirrhosis. Its role in these diseases involves connections with proteins like ALT (Alanine Transaminase) and AST (Aspartate Transaminase) which are often elevated in liver damage. Identifying hepatocyte markers allows researchers to explore disease mechanisms progression and treatment responses enhancing our understanding of liver-specific pathologies.