Abcam, ab191417, Anti-ATP5L2 + ATP5L antibody [EPR15636]

Size: 10µL-TRIAL / 100µL / 1mL
Rabbit Recombinant Monoclonal ATP5L2 antibody. Suitable for IP, WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15636,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATP5L2 and ATP5L are subunits of the mitochondrial ATP synthase complex also known as Complex V which plays an important role in cellular energy production. ATP5L also known as OLigo1 consists of approximately 19 kDa mass. ATP5L2 has a similar role and size. Both subunits are essential parts of the F1F0 ATP synthase complex located in the inner mitochondrial membrane. These proteins are expressed in tissues with high energy demands such as cardiac and skeletal muscles liver and neuronal tissue.
Biological function summary
These subunits contribute to ATP synthesis which is critical for providing the energy required for various cellular functions. They are integral parts of the F1F0 ATP synthase complex which couples proton transport across the inner mitochondrial membrane to ATP generation from ADP and inorganic phosphate. This process is important for maintaining cellular energy balance and disruptions can lead to impaired cellular functions or energy deficits.
Pathways
ATP5L and ATP5L2 are integral to the oxidative phosphorylation pathway part of cellular respiration. This pathway is critical for efficient ATP production and involves other complexes such as NADH dehydrogenase and cytochrome c oxidase. These subunits interact with essential proteins like ATP5B another ATP synthase subunit ensuring the ATP synthase complex properly functions within this pathway.
Altered expression or mutations in ATP synthase complex components including ATP5L and ATP5L2 can link to metabolic disorders such as mitochondrial myopathy and neurodegenerative diseases like Alzheimer's. These disorders often involve other proteins such as cytochrome c and amyloid precursor protein which further disrupt mitochondrial function and cellular energy homeostasis. Understanding these connections provides insight into the potential therapeutic targets for these conditions.