Abcam, ab191691, Anti-UBIAD1 antibody - C-terminal

Size: 100µg
Rabbit Polyclonal UBIAD1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human UBIAD1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human UBIAD1. The exact immunogen used to generate this antibody is proprietary information.Q9Y5Z9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBIAD1 also known as UbiA prenyltransferase domain-containing protein 1 is a human gene encoding an enzyme with an important role in cellular processes. This enzyme has a mass of approximately 32 kDa and is expressed in various tissues including liver kidney and heart. UBIAD1 is involved in the synthesis of menaquinone-4 (MK-4) a form of vitamin K2 and it participates in cholesterol metabolism. Through its function this enzyme contributes to the production of coenzyme Q10 essential for mitochondrial energy production.
Biological function summary
UBIAD1 helps regulate lipid metabolism and cellular oxidative stress responses. The protein does not form a larger complex but functions independently to facilitate the biosynthesis of specific lipids. Its role in managing oxidative stress is particularly important as it can impact the production of reactive oxygen species within cells. By maintaining the balance of cellular lipids and redox states UBIAD1 supports overall cell health.
Pathways
UBIAD1 acts in both the mevalonate pathway and the vitamin K cycle. In the mevalonate pathway UBIAD1 contributes to the production of cholesterol and non-sterol isoprenoids. It works alongside related proteins such as HMG-CoA reductase a critical enzyme in cholesterol biosynthesis. UBIAD1 also plays a role in the vitamin K cycle which is important for activating clotting factors necessary for blood coagulation. This involvement highlights its participation in key metabolic and regulatory pathways.
Mutations in UBIAD1 can lead to Schnyder corneal dystrophy (SCD) a rare genetic disorder characterized by progressive opacification of the cornea. Research indicates that abnormal UBIAD1 function can disrupt cholesterol metabolism resulting in crystalline deposits in the cornea. Additionally UBIAD1 has connections to cardiovascular diseases due to its role in cholesterol regulation. Proteins such as apolipoprotein E (ApoE) may interact with UBIAD1 in the context of these disorders influencing lipid transport and metabolism.