Abcam, ab191856, Anti-ATMIN antibody - N-terminal

Size: 100µg
Rabbit Polyclonal ATMIN antibody. N-terminal. Suitable for ICC, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATMIN.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ATMIN. The exact immunogen used to generate this antibody is proprietary information.O43313

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATMIN also referred to as ASCIZ (ATM Substrate Chk2-Interacting Zn2+-finger protein) is a protein of approximately 96 kDa. It functions mechanically as a transcription factor regulating the expression of various genes. ATMIN is expressed in multiple tissues but shows high expression in the brain and testes. It plays a role in maintaining cellular homeostasis through its regulation of gene transcription and DNA damage response.
Biological function summary
ATMIN interacts with proteins involved in DNA repair mechanisms. It forms a part of the DNA damage response pathway and modulates activities to maintain genomic integrity. ATMIN's ability to engage with ATM (Ataxia-Telangiectasia Mutated) protein is significant for its function. Through its interaction with ATM ATMIN regulates cellular responses to genotoxic stress contributing to DNA repair cell cycle regulation and apoptosis.
Pathways
ATMIN's role links closely to the DNA damage response and oxidative stress pathways. It cooperates with ATM kinase which acts as a central player in these pathways. By partnering with ATM ATMIN facilitates repair processes and stabilizes the genome. Moreover ATMIN's regulation of transcription factors influences oxidative stress response integrating with broader cellular mechanisms for maintaining cellular integrity under stress conditions.
ATMIN has implications in cancer and neurodegenerative diseases. Altered function or expression of ATMIN can contribute to tumorigenesis due to impaired DNA repair processes. Its interaction with ATM becomes critical in understanding its contribution to such pathologies. Furthermore ATMIN's involvement in oxidative stress response pathways links it to neurodegenerative diseases where oxidative damage is a contributing factor. Understanding these relationships can lead to better therapeutic strategies targeting ATMIN and associated pathways.