Abcam, ab19346, Anti-HCN2 antibody

Size: 100µg
Rabbit Polyclonal HCN2 antibody. Suitable for WB, ICC/IF and reacts with Rat, Mouse samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human HCN2 aa 850 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HCN2 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9UL51

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HCN2 also known as hyperpolarization-activated cyclic nucleotide-gated channel 2 is a protein that forms part of the HCN channel family. These channels are responsible for generating the I_h current in cardiac and neuronal tissues. The HCN2 protein has a molecular mass of approximately 97 kDa. It is prominently expressed in the heart and brain particularly in the sinoatrial node of the heart and various neurons in the brain's central nervous system.
Biological function summary
The HCN2 channel influences the rhythmic activity of cardiac pacemaker cells and certain types of neurons. It belongs to a larger complex of ion channels that contribute to the cardiac pacemaking process and synchronization of neuronal firing. The HCN channels facilitate the flow of potassium and sodium ions which is critical for modulating electrical excitability and rhythmic oscillations in these cells.
Pathways
HCN2 plays a significant role in both cardiac and neurological pathways. In the cardiac context it is part of the heart rate regulation pathway cooperating with other proteins such as HCN4 for managing the heart's rhythmic cycle. Neurologically HCN2 influences the pathway responsible for synaptic transmission and neuronal excitability interfacing with proteins like TRIP8b which modulate the activity of HCN channels in the neurons.
HCN2 shows connections to conditions such as cardiac arrhythmias and pain disorders. Disruptions in HCN2 function may lead to irregular heartbeats or contribute to chronic pain disorders due to its role in modulating electrical excitability. In pain-related pathways it interacts with other ion channels like Nav1.7 which are critical in the pathway of pain signaling and transmission across neurons.