Abcam, ab194111, Anti-HES5 antibody [EPR15578]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal HES5 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 31 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15578,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HES5 protein also known as Hairy and Enhancer of Split 5 represents a transcriptional repressor involved in various cellular processes. Having a molecular weight of around 30 kDa HES5 is part of the basic helix-loop-helix (bHLH) family of transcription factors. Its expression predominantly occurs in the nervous system specifically in neural progenitor cells. Additionally HES5 also shows expression in certain tissues during early developmental stages.
Biological function summary
The HES5 protein influences neurogenesis by regulating the transcription of genes involved in developmental pathways. It does not work alone but as part of a larger complex of proteins specifically within the Notch signaling pathway. When active HES5 suppresses the expression of proneural genes thereby maintaining neural progenitor cells in an undifferentiated state an important function for proper neural development. This regulatory role is essential for ensuring the balance between neural progenitor proliferation and differentiation.
Pathways
HES5 functions significantly within the Notch signaling and Wnt pathways which are critical to cellular differentiation and proliferation. The Notch signaling pathway includes interactions with related proteins like Notch receptors and ligands such as DLL1 and JAG1. These interactions modulate gene expression that governs neural stem cell maintenance and differentiation. Within the Wnt pathway HES5 indirectly influences signaling that affects cellular fate decisions showing the protein’s role in developing a cellular environment conducive to tissue repair and regeneration.
HES5 has associations with central nervous system disorders like glioblastoma and neurodegenerative diseases. In glioblastoma altered expression of HES5 contributes to the aberrant regulation of neural progenitor states influencing tumorigenesis. HES5's role in neurodegenerative diseases links to its regulatory control over neurogenesis potentially affecting conditions such as Alzheimer's disease. Connections with other proteins such as NOTCH1 in glioblastoma indicate the complex interplay of HES5 within these disease states.