Abcam, ab194292, Anti-C14orf169 / NO66 antibody [EPR18754]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal C14orf169 / NO66 antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18754,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C14orf169 also known as NO66 is a nuclear protein implicated in chromatin regulation and protein synthesis. It has an estimated molecular mass of approximately 85 kDa. This protein shows widespread expression in various tissues including high levels in the brain and liver. C14orf169 possesses JmjC domain which provides it with demethylase activity influencing histone modifications that are critical for chromatin structure and gene expression regulation.
Biological function summary
C14orf169 functions as a part of nuclear complexes involved in transcriptional regulation. It interacts with other chromatin-associated factors ensuring proper histone modification which is necessary for modulating gene expression. This protein's role in regulating chromatin's epigenetic state connects it to important cellular processes such as cell cycle progression and response to stress.
Pathways
C14orf169 integrates within histone modification and transcriptional regulation pathways. Its demethylase activity influences the H3K4me3 and H3K36me3 marks important for transcriptional activation or repression. C14orf169 shows interactions with other proteins such as histone demethylases and methyltransferases that cooperate in modifying chromatin structure affecting gene transcription patterns.
C14orf169's dysregulation associates with cancer types including prostate cancer. Changes in its expression may lead to altered chromatin states affecting oncogene and tumor suppressor gene regulation. Additionally C14orf169 connects with ubiquitin-proteasome pathways implicating it in neurodegenerative disorders where protein degradation becomes impaired specifically in conditions like Alzheimer's disease.