Abcam, ab194333, Anti-5-HT-2B antibody - Extracellular domain

Size: 50µL
Mouse Polyclonal 5-HT-2B antibody. Extracellular domain. Suitable for WB and reacts with Recombinant fragment - Human, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HTR2B aa 1-100.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HTR2B aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P41595

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
5-HT-2B also known as serotonin receptor 2B is a G-protein-coupled receptor that binds to serotonin. This protein with a molecular mass of approximately 55 kDa is located on the cell surface and exhibits a wide expression in tissues such as the heart lung liver and gastrointestinal tract. It contains several functional domains contributing to its activity mediating cellular responses through signaling cascades when serotonin binds to it.
Biological function summary
5-HT-2B plays a role in modulating the contractility and remodeling of cardiac tissue influencing vascular function and smooth muscle behavior impacting gastrointestinal motility and contributing to liver regeneration. It is not part of a large multiprotein complex but interacts with other cellular components to exert its biological functions. The receptor's activation leads to various intracellular responses influencing different physiological effects depending on the tissue context.
Pathways
Serotonin receptor 2B is involved in the serotonin signaling pathway and the calcium signaling pathway. These pathways impact several physiological processes including mood regulation and cardiovascular function. The receptor interacts with proteins such as phospholipase C which mediates the hydrolysis of phospholipids in the membrane releasing inositol trisphosphate and causing a rise in intracellular calcium levels important for function continuation.
Abnormalities in 5-HT-2B have been linked to cardiac valvulopathy and pulmonary hypertension. These conditions highlight the importance of its role in vascular and cardiac function. The receptor's dysregulation interacts with proteins such as endothelin-1 in vascular abnormalities and contributes to disease progression highlighting its potential as a target for therapeutic interventions in these disorders.