Abcam, ab194425, Anti-ARHGAP1 antibody

Size: 50µL
Mouse Polyclonal ARHGAP1 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGAP1 aa 300 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARHGAP1 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q07960

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARHGAP1 also known as Rho GTPase-activating protein 1 plays an important role in the regulation of the Rho family of GTPases. These proteins control the actin cytoskeleton affecting cell shape and migration. ARHGAP1 acts as a GTPase-activating protein stimulating the GTPase activity of Rho-type GTPases and thereby controls their signaling activity. The protein weighs about 48 kDa and shows expression in various tissues including lung heart and liver.
Biological function summary
ARHGAP1 contributes to cell movement processes such as migration and invasion. It is part of a regulatory complex that modulates the signaling pathways involving actin cytoskeletal dynamics. ARHGAP1 interacts with key molecules in pathways that manage cell adhesion and motility indicating its role in cellular dynamics and structural integrity.
Pathways
ARHGAP1 actively participates in the Rho GTPase cycle interacting with proteins like Cdc42 and Rac which are involved in controlling actin polymerization dynamics. The protein plays a role in pathways like the VEGF signaling pathway influencing how cells respond to growth signals. It provides an intersection between small GTPase signaling and cytoskeletal rearrangement essential for cell movement and stability.
ARHGAP1 shows associations with cancer progression and metastasis. Changes in ARHGAP1 expression can influence the behavior of cancer cells increasing their migratory and invasive capabilities. In addition ARHGAP1 connects with the protein EGFR where aberrant pathways involving these proteins can lead to non-small cell lung cancer. In this context it is important to further investigate ARHGAP1's roles to understand its potential use in therapeutic developments.