Abcam, ab194664, Anti-RPL21 antibody

Size: 50µL
Mouse Polyclonal RPL21 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RPL21 aa 1-100.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RPL21 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P46778

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The RPL21 protein also known as 60S ribosomal protein L21 forms part of the ribosomal 60S subunit. This protein weighs approximately 18 kDa. It expresses in various tissues with significant expression in rapidly dividing cells where ribosome production is higher. RPL21 is involved in protein synthesis by contributing to the assembly of ribosomes facilitating the translation of messenger RNA into proteins.
Biological function summary
RPL21 has a significant role in ribosome biogenesis and function. It is a component of the large ribosomal subunit complex which consists of numerous proteins and RNA molecules. This complex translocates along mRNA strands to facilitate the synthesis of polypeptide chains. RPL21's presence in the ribosome is essential for maintaining the structural integrity needed for efficient translation processes.
Pathways
RPL21 acts within the mRNA translation pathway and is important in the ribosome assembly pathway. It interacts directly with other ribosomal proteins such as RPL5 and RPL11 aiding the coordination and assembly of the 60S ribosomal subunit. The ribosome assembly pathway is fundamental in cell growth and division linking RPL21 with regulatory pathways that control protein synthesis rates.
Mutations or dysregulation of RPL21 associate with diamond-blackfan anemia and certain cancers. In diamond-blackfan anemia defective ribosomal proteins like RPL21 lead to impaired ribosome assembly resulting in decreased erythrocyte production. In cancer altered expression of RPL21 may connect with oncogenic pathways where it interacts with proto-oncogenes or tumor suppressors that drive tumorigenesis.