Abcam, ab194813, Anti-LRRC32 antibody [GARP5]

Size: 100µg
Mouse Monoclonal LRRC32 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human LRRC32.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:GARP5,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human LRRC32.Q14392

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-ab194813 was purified from cell culture supernatant by protein-A affinity chromatography. Purity is > 95% (by SDS-PAGE)., Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LRRC32 also known as GARP (Glycoprotein A Repetitions Predominant) is a membrane protein with an approximate mass of 80 kDa. Scientists observe its expression mostly on regulatory T cells (Tregs) platelets and activated B cells. As an integral membrane protein LRRC32 plays an important role in cellular processes by anchoring latent transforming growth factor-beta (TGF-β) on the cell surface which is important for its regulation and activation.
Biological function summary
LRRC32 functions as part of a larger protein complex that regulates immune responses. By controlling the availability of TGF-β LRRC32 contributes directly to maintaining immune homeostasis and tolerance. Its presence on Tregs enables these cells to modulate immune responses effectively preventing excessive immune activity which could lead to autoimmune disorders. Hence LRRC32 serves as an important component in immune regulation through its interaction with and presentation of TGF-β.
Pathways
The activity of LRRC32 aligns with critical immune signaling pathways including the TGF-β signaling pathway and the FoxP3 regulatory pathway. In the TGF-β pathway it associates with other proteins like TGF-β receptor to mediate downstream signaling that influences cell growth differentiation and immune suppression. Additionally through its indirect interaction with the FoxP3 regulatory network LRRC32 aids in stabilizing Tregs and promoting their suppressive function within the immune system which involves the lineage-specific transcription factor FoxP3.
LRRC32 is relevant in conditions such as cancer and autoimmune diseases. Its association with TGF-β and FoxP3 makes it a potential target in cancer where excessive TGF-β activity might promote tumor progression and immune evasion. Conversely inadequate function of LRRC32 or TGF-β signaling could contribute to autoimmune diseases by failing to suppress harmful immune responses effectively. Its relation to GARP and TGF-β highlights its significant role in both the initiation and progression of these diseases direct implication in disease pathology and therapeutic targeting.