Abcam, ab194938, Anti-TPD52L2 antibody

Size: 100µg
Rabbit Polyclonal TPD52L2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TPD52L2 aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TPD52L2 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O43399

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab194938 was affinity purified using an epitope specific to TPD52L2 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein TPD52L2 also known as Tumor Protein D52-like 2 and PrLZ plays a role in intracellular transport and secretion by interacting with membranes and acting as a vesicle-associated protein. It has a molecular weight of approximately 24 kDa. TPD52L2 gets highly expressed in several tissues including pancreas prostate and hematopoietic system. Moreover TPD52L2 localizes in cytoplasm and associates with secretory granules and lysosomal membranes.
Biological function summary
TPD52L2 contributes to processes such as cell proliferation and survival. It is associated with the regulation of exocytosis because of its presence in vesicles. TPD52L2 forms part of a broader protein family with conserved coiled-coil domains suggesting a capacity for protein-protein interactions. This family can affect the organization and dynamics of the cytoskeleton which is important for cytokinesis and endocytosis.
Pathways
TPD52L2 interacts directly with cellular communication and transport pathways. It is known to participate in the tumorigenesis pathway by modulating cell growth and apoptosis. The protein has interactions with key components such as PKB/AKT an important player in signaling cascades that regulate cell survival and metabolism. As a part of these pathways TPD52L2 may contribute to oncogenic transformation.
TPD52L2 has implications in cancer and metabolic disorders. Elevated levels of TPD52L2 have been linked to prostate cancer development where it interacts with proteins like FAK which are important for cancer cell migration and spread. Additionally altered expression of TPD52L2 could impact insulin signaling pathways contributing to conditions such as diabetes. Here its association with IRS proteins further illustrates the impact TPD52L2 may have within these pathologies.