Abcam, ab194957, Anti-ORP-11 antibody - N-terminal

Size: 100µg
Rabbit Polyclonal ORP-11 antibody. N-terminal. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OSBPL11 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human OSBPL11 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9BXB4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab194957 was affinity purified using an epitope specific to ORP-11 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ORP-11 also known as oxysterol-binding protein-related protein 11 is a lipid-binding protein involved in intracellular lipid transport. It has a mass of approximately 52 kDa. ORP-11 is expressed in various tissues with notable expression in the brain as well as in the liver. It functions at cellular membranes where it facilitates the transfer and regulation of specific lipids maintaining cellular homeostasis.
Biological function summary
Oxysterol-binding protein-related protein 11 is part of a broader family which plays roles in lipid sensing and signaling. It potentially interacts with and forms complexes with other member proteins within this family allowing for coordination in lipid transport and metabolism. ORP-11 is essential in maintaining proper lipid balance in cells influencing signaling pathways that depend on lipid molecules as messengers.
Pathways
ORP-11 participates in the PI3K/Akt signaling pathway which is important for cell survival and growth. It also fits into lipid metabolism pathways where it interacts with proteins like PI4P and other OSBP family members. These interactions are important for the regulation of phosphoinositides affecting the cell's membrane dynamics and intracellular signaling processes.
ORP-11 has been linked to metabolic disorders including non-alcoholic fatty liver disease (NAFLD). Disruptions in ORP-11 function may result in improper lipid metabolism contributing to the pathogenesis of this liver disorder. Additionally it is associated with certain neurological conditions as its expression in the brain suggests it may interact with proteins like ApoE which plays a role in neurodegenerative diseases. ORP-11's involvement in lipid regulation pathways highlights its importance in maintaining cellular function and its potential connection to disease development.