Abcam, ab194967, Anti-Kindlin 2 antibody

Size: 100µg
Rabbit Polyclonal Kindlin 2 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FERMT2 aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FERMT2 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.Q96AC1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kindlin-2 also known as FERMT2 is a mechanistic component involved in cellular adhesion processes. This protein has a molecular weight of approximately 75 kDa. Kindlin-2 is found in various tissues with high expression in epithelial cells and muscle tissues. It works together with integrins to maintain cell adhesion to the extracellular matrix performing an important role in cell communication with its surroundings.
Biological function summary
Kindlin-2 contributes to integrin activation and cytoskeletal organization by forming part of a larger complex. This complex stabilizes integrin-talin interactions enhancing the affinity of integrins for their ligands. This function of Kindlin-2 aids in dynamically regulating cell shape migration and mechanical signaling. Its role is significant for normal cellular function and homeostasis because it helps cells to attach and detach when necessary which is important for cell movement and tissue repair.
Pathways
The action of Kindlin-2 integrates with key signaling pathways like the Wnt and PI3K/AKT pathways. In these pathways Kindlin-2 assists in transmitting signals necessary for cellular proliferation and survival. It interacts with other proteins such as talin and integrin β subunits forming a bridge between the cytoskeleton and external signals. This interaction allows cells to adapt to changes in their environment by modulating cell adhesion and migration.
Kindlin-2's function relates to conditions such as cancer and fibrosis. In cancer Kindlin-2 aids tumor cell migration and metastasis linking it to the pathological spread of cancerous cells. In fibrosis Kindlin-2 influences the excessive deposition of extracellular matrix components contributing to tissue scarring. The protein also interacts with fibronectin and collagens in these contexts showing its involvement in extracellular matrix remodeling and pathological tissue changes.