Abcam, ab196013, Anti-ILKAP antibody [EPR16145]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ILKAP antibody. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16145,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ILKAP also known as integrin-linked kinase-associated phosphatase is a 43 kDa protein phosphatase. It regulates cell signaling pathways by dephosphorylating specific substrates. It is expressed in various tissues including the heart brain and skeletal muscle. ILKAP specifically interacts with the integrin-linked kinase (ILK) impacting cytoskeletal dynamics and cell adhesion processes.
Biological function summary
The phosphatase activity of ILKAP plays a role in cellular adhesion and movement. ILKAP participates in cellular processes by associating with the ILK complex which includes other key proteins like paxillin and parvin. By modulating the phosphorylation state of substrates within this complex ILKAP influences focal adhesion dynamics and cytoskeletal organization which are critical for maintaining cellular architecture and motility.
Pathways
ILKAP acts within the integrin signaling and Wnt signaling pathways. These pathways are important in regulating cell movement differentiation and survival. ILKAP interacts with proteins like β-catenin in the Wnt pathway influencing gene expression critical for cell fate determination. Additionally ILKAP works alongside ILK in the integrin signaling pathway to affect cellular responses like proliferation and migration.
ILKAP has connections to cancer and cardiovascular diseases. Its regulatory role in cell adhesion and movement links it to cancer metastasis where the altered adhesion leads to the spread of cancer cells. ILKAP also interacts with ILK influencing mechanisms related to tissue remodeling and inflammation in cardiovascular diseases. These associations highlight ILKAP as a potential target for therapeutic intervention in these conditions.