Abcam, ab196589, Anti-Tbp7 antibody

Size: 100µL
Rabbit Polyclonal Tbp7 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tbp7 also known as Tat-binding protein 7 is an essential component linked to various cellular processes. It has a molecular mass of about 76 kDa and is found in many tissues with significant expression in the brain and immune cells. It operates mechanically by interacting with components of the cellular machinery to influence transcription regulation and growth signaling. Tbp7's involvement in these processes highlights its importance in maintaining cellular homeostasis.
Biological function summary
Tbp7 plays an important role in the ubiquitin-proteasome system contributing to protein degradation and turnover. It forms a part of the ATP-dependent proteasome activator complex where it collaborates with other proteins like PSMC components to regulate protein breakdown. This system ensures the removal of damaged or unneeded proteins thereby protecting cells from stress and maintaining protein quality control.
Pathways
Tbp7 directly influences pathways such as the NF-kB signaling pathway and the mTOR pathway. It interacts with proteins like IkB and mTOR which are pivotal for controlling inflammation and autophagy respectively. By modulating these pathways Tbp7 helps balance cellular responses to stress and nutrient conditions reflecting its role as a regulator in cell survival and growth.
Researchers link Tbp7 to neurodegenerative diseases and certain immune disorders. Alterations in Tbp7 function can disrupt protein degradation exacerbating conditions like Alzheimer's disease and lupus. Proteins such as beta-amyloid in Alzheimer’s and immune cell activators in lupus are affected through Tbp7’s regulation of protein decay pathways highlighting its contribution to disease pathophysiology.