Abcam, ab196593, Anti-CDON / Cdo antibody

Size: 100µL
Rabbit Polyclonal CDON / Cdo antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CDON.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CDON. The exact immunogen used to generate this antibody is proprietary information.Q4KMG0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CDON also known as Cdo is a cell surface receptor that is part of the immunoglobulin superfamily. It typically has a mass of approximately 135 kDa. This receptor expresses mainly in developing and adult tissues that involve muscle and neuronal differentiation such as skeletal muscle and nervous system tissues. CDON possesses the ability to interact with extracellular matrix components contributing to its role in cellular adhesion events.
Biological function summary
The CDON protein acts as a part of a larger multi-protein complex. It is involved in pathways that regulate myogenic differentiation cell adhesion and cell signaling. CDON supports skeletal muscle development by facilitating interactions between cells and extracellular signals that guide cells towards the muscle lineage. It interacts with other proteins like Boc and Gas1 which help in modulating downstream signaling pathways important for proper tissue development.
Pathways
CDON plays a significant role in the Hedgehog signaling and Wnt signaling pathways. These pathways are essential for various cellular processes including tissue patterning and cellular proliferation. In the context of these pathways CDON associates with proteins such as Smoothened and Patched which serve as major constituents of Hedgehog signal transduction enabling the precise regulation of cellular responses during development.
CDON is associated with congenital conditions like holoprosencephaly and certain cancers particularly rhabdomyosarcoma. CDON interacts with proteins involved in these disorders such as SHH (Sonic Hedgehog) which plays a central role in the coordination of tissue growth and architecture. Disruptions in CDON-mediated pathways can lead to developmental anomalies or influence the progress of malignant transformations in tissues underlining its importance in both normal development and pathogenesis.