Abcam, ab196657, Anti-POLR1C antibody [EPR16178]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal POLR1C antibody. Suitable for WB and reacts with Rat, Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR16178,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
POLR1C also known as RNA polymerase I and III subunit C functions as a component of RNA polymerases I and III essential for the synthesis of ribosomal RNA precursors and small RNAs. This protein weighs approximately 34.5 kDa and is found ubiquitously expressed in human tissues reflecting its fundamental role in cellular transcription machinery. POLR1C is a subunit important for these polymerases' proper assembly and function.
Biological function summary
POLR1C participates in the formation of the RNA polymerase I and III complexes which are responsible for transcribing ribosomal RNA and small RNAs respectively. These processes are important for protein synthesis and cell growth. As part of these complexes POLR1C interacts with multiple other subunits to ensure the correct transcription of ribosomal RNA which forms the structural and functional core of ribosomes essential for translating mRNA into proteins.
Pathways
POLR1C is integral to the transcription pathways specifically those conducted by RNA polymerases I and III. These pathways play an important role in the synthesis of ribosomal RNA and small RNAs which are critical for protein biosynthesis. In these processes the protein interacts with other components like RPA proteins as well as RPC5 highlighting its involvement in the transcription cycle critical for cellular function and maintenance.
POLR1C mutations have connections to Treacher Collins syndrome and hypomyelinating leukodystrophy. In Treacher Collins syndrome POLR1C interacts with proteins involved in ribosomal biogenesis disrupting this process and causing craniofacial development issues. Similarly in hypomyelinating leukodystrophy aberrations in ribosomal RNA synthesis contribute to neurological symptoms further implicating POLR1C’s pivotal role in transcription machinery and development.