Abcam, ab196842, Anti-MRPL28 antibody

Size: 100µL
Rabbit Polyclonal MRPL28 antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MRPL28.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human MRPL28.Q13084

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPL28 also known as Mitochondrial Ribosomal Protein L28 is a component of the mitochondrial ribosome. It plays a critical role in protein synthesis within mitochondria. The protein has a molecular mass of about 32 kDa. MRPL28 is expressed in many tissues with higher expression levels observed in tissues with high energy demands such as the heart muscles and liver.
Biological function summary
MRPL28 integrates into the large subunit of the mitochondrial ribosome forming part of the machinery required for mitochondrial protein synthesis. This protein is essential for the production of proteins encoded by mitochondrial DNA. MRPL28 functions within the larger mitochondrial ribosomal complex which is distinct from cytoplasmic ribosomes highlighting its specialized role in maintaining mitochondrial function.
Pathways
The function of MRPL28 is closely tied to the oxidative phosphorylation pathway. This pathway involves the production of ATP via electron transport and chemiosmosis in the mitochondria. MRPL28 directly interacts with other mitochondrial ribosomal proteins to facilitate the translation of mitochondrial-encoded proteins essential for electron transport chain complexes. Changes in MRPL28 expression or function can impact energy metabolism and cellular homeostasis.
Mutations or dysregulation in MRPL28 have been associated with mitochondrial diseases such as mitochondrial myopathy. These disorders often affect energy-intensive tissues leading to symptoms such as muscle weakness or heart problems. Furthermore MRPL28 has connections to neurodegenerative diseases where mitochondrial dysfunction could play a role in disease progression. Understanding the link between MRPL28 and these conditions may offer insights into potential therapeutic strategies.