Abcam, ab196984, Anti-IFNL4 antibody [51-1]

Size: 10µg-TRIAL / 100µg / 1mg
Rabbit Recombinant Monoclonal IFNL4 antibody. Suitable for BL, WB and reacts with Human, Synthetic peptide samples. Cited in 10 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:51-1,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, BLSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
This product has switched from a hybridoma to recombinant production method on 6th January 2021.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IFNL4 also known as Interferon Lambda 4 plays an important role in the immune system. This protein with a mass of approximately 22 kDa is part of the type III interferon family. It expresses mainly in liver cells and epithelial tissues. IFNL4 is involved in the antiviral defense mechanism of the body. It shows activity by binding to the IFN lambda receptor complex initiating a response that helps control viral infections.
Biological function summary
IFNL4 acts as a cytokine and contributes to modulating immune responses. It is not part of a complex but interacts closely with the IFN lambda receptor to activate Janus kinase and signal transducer and activator of transcription (JAK-STAT) signaling pathways. This activation leads to the promotion of antiviral responses in infected cells and limits viral spread. Understanding its signaling function clarifies its important impact on immune defense.
Pathways
IFNL4 is fundamental to the JAK-STAT signaling pathway and to the innate immune response pathway. These pathways mediate cellular responses to viral infections. IFNL4 interacts with other proteins like IFNLR1 IL10RB and STAT1 which are essential for these pathways. By engaging these pathways IFNL4 helps control the expression of genes involved in antiviral defense such as those coding for interferon-stimulated genes (ISGs).
IFNL4 has strong connections to hepatitis C virus (HCV) infection and liver fibrosis. Researchers found that the expression of IFNL4 can influence the outcome of HCV infection affecting viral clearance and treatment response. Another related protein IFNL3 also interacts with these pathways and together they provide insights into the genetic factors influencing liver fibrosis progression. Understanding IFNL4's role provides opportunities to develop targeted therapies for these conditions.